解构外围神经损伤后前带带皮质前三层的前进抑制变化
Yan-Na Lian1,2, Xiao-Wen Cao1,2, Cheng Wu1,3
1Department of Psychiatry, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China.
Communications biology
|October 1, 2024
概括
周围神经损伤增强了从中背丘脑 (MD) 到前环皮质 (ACC) 的信号,增加了疼痛敏感性. 调节这些信号提供了潜在的疼痛缓解策略.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 突触性可塑性 突触性可塑性
背景情况:
- 前环皮质 (ACC) 对于处理有害刺激至关重要.
- 已知外周神经损伤会导致ACC的广泛变化,导致疼痛过敏.
- 在ACC中的3层 (L3) 神经元从中脊丘脑 (MD) 接收输入,并参与前进抑制 (FFI) 微电路.
研究的目的:
- 为了研究外围神经损伤对中背丘脑 (MD) 驱动的前皮质 (ACC) 3 层 (L3) 的前带皮质前进抑制 (FFI) 的影响.
- 为了确定MD-to-ACC投影在疼痛过敏和疼痛厌恶后的外围神经损伤中的作用.
主要方法:
- 利用小鼠外围神经损伤模型 (常见的周围神经绑定).
- 记录了从ACC的MD到L3的突触传输.
- 采用化学遗传学来激活或禁用MD-to-ACC投射在幼稚和神经受伤的小鼠.
- 评估疼痛敏感性和地方偏好/厌恶行为.
主要成果:
- 周围神经损伤导致了从ACC的MD到L3的激发性突触传输的增强,破坏了FFI.
- 化学遗传激活MD-to-ACC投影诱导疼痛敏感性和地方厌恶在天真的小鼠.
- 在神经受伤的小鼠中,MD-to-ACC投影的化学遗传失活化降低了疼痛敏感性,并促进了位置偏好.
结论:
- 周围神经损伤改变了MD-to-ACC预测,导致疼痛过敏和厌恶的发展.
- MD-to-ACC途径是神经病痛背后的神经回路的关键参与者.
- 针对MD-to-ACC预测可能是治疗慢性疼痛症的治疗策略.
相关概念视频
01:15Neurogenesis and Regeneration of Nervous Tissue
2.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.1K
01:14Spinal Cord Injury ll: Pathophysiology
25
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
25
01:25Secondary Spinal Cord Injury llI: Pathophysiology
52
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
52