内皮功能障碍在睡眠呼吸障碍中的作用 在埃及患有状细胞病的儿童中
Ilham Youssry1, Abla S Mostafa2, Dina H Hamed2
1Department of Pediatric Hematology, Faculty ofMedicine, Cairo University, Giza, Egypt.
BMC pediatrics
|October 1, 2024
概括
患有状细胞疾病 (SCD) 的儿童患有睡眠呼吸障碍 (SDB) 的患病率很高. SDB与这些儿童内皮功能障碍标志物增加有关.
科学领域:
- 儿科血液学 儿科血液学
- 睡眠医学 睡眠医学
- 心血管研究研究心血管研究
背景情况:
- 内皮功能障碍是状细胞疾病 (SCD) 并发症的关键因素.
- 睡眠呼吸障碍 (SDB) 是SCD的一个已知的并发症,表现不同.
- 儿科SCD中SDB和内皮功能障碍之间的关系需要进一步调查.
研究的目的:
- 确定患有SCD的儿童中SDB的流行率.
- 评估SDB和儿科SCD中的内皮功能障碍标志物之间的关联.
- 探索特定的SDB症状及其与炎症标志物的相关性.
主要方法:
- 招募了60名患有SCD的儿童和60名健康对照.
- 使用ELISA套件测量了TNF-α,IL-6和IL-17A的血清水平.
- 对SCD患者进行了儿科睡眠问卷 (PSQ) 和进行了多睡眠图 (PSG).
主要成果:
- 与对照组相比,患有SCD的儿童的TNF-α,IL-6和IL-17A水平显著更高.
- 在83.3%的SCD儿童中,PSQ显示了SDB症状;PSG在73.3%的儿童中证实了阻塞性睡眠呼吸暂停 (OSA).
- 提升的TNF-α,IL-6和IL-17A水平与特定的SDB症状相关,如呼吸困难,生长障碍和早晨头痛.
结论:
- 儿科SCD患者显示SDB的高患病率.
- 升高的炎症标志物表明SDB和SCD中的内皮功能障碍之间存在显著的相互作用.
- 这些发现强调了对患有SCD的儿童进行SDB查的重要性,以解决相关的内皮功能障碍.
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