妊娠糖尿病与早产复杂化:一个回顾性队列研究
Shuyao Huang1,2, Yanni Guo1, Xia Xu1
1Fujian Provincial Maternity and Children's Hospital, No. 18, Daoshan Road, Gulou District, Fuzhou, Fujian Province, 350001, China.
BMC pregnancy and childbirth
|October 1, 2024
概括
孕期糖尿病 (GDM) 增加了早产 (PTB) 的风险,特别是早期的PTB,与高血压疾病和脂质变化有关. 对患有贫血等并发症的GDM患者进行密切监测至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 内分泌学 在内分泌学.
背景情况:
- 孕期糖尿病 (GDM) 是妊娠不良结果的重要危险因素.
- 过早分娩 (PTB) 仍然是新生儿发病率和死亡率的主要原因.
- 了解患有GDM的女性PTB的特定临床特征对于有针对性的干预措施至关重要.
研究的目的:
- 在孕期糖尿病 (GDM) 的背景下,描述早产 (PTB) 的临床特征.
- 确定与GDM怀孕中早期与晚期PTB相关的风险因素和临床标志物.
主要方法:
- 对14314名患有GDM的孕妇进行了回顾性队列研究.
- PTB分为早期 (<34周) 和晚期 (34-36周) 的妊娠阶层.
- 对妊娠并发症,脂质样本和炎症标志物的分析.
主要成果:
- 与到期分娩相比,PTB队列显示出更高的膜过早破裂率,妊娠高血压疾病 (HDP),妊娠肝内胆固醇症 (ICP),贫血和宫功能不充分.
- 早期PTB与晚期PTB相比,与HDP,ICP,贫血和宫衰竭的发病率增加有关.
- 早期PTB在怀孕早期和晚期分别表现出改变的脂质特征 (高甘油,降低HDL-C) 和炎症标志物 (增加WBC,中性粒细胞).
结论:
- 加强GDM的监测和管理,特别是对于那些患有HDP,ICP和贫血的人来说,对于降低PTB风险至关重要.
- 怀孕早期的脂质样本可以预测GDM患者早期的PTB.
- 需要进一步的研究来验证脂质配置文件作为早期PTB的预测工具.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Pathophysiology of Diabetes
894
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
894
Diabetes: Symptoms, Diagnosis, and Complications
515
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
515
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K


