黄素提取物改善2型糖尿病肥胖患者的β细胞功能:一项随机对照试验
Metha Yaikwawong1, Laddawan Jansarikit1, Siwanon Jirawatnotai1,2,3
1Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
库尔库明补充剂在12个月内显著降低了2型糖尿病患者的血糖和HbA1c. 这种天然化合物改善了胰岛素敏感性,β细胞功能,并减少了体重,副作用最小.
科学领域:
- 代谢健康 代谢健康
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2DM) 是一种代谢障碍,其特征是胰岛素抵抗和胰岛素分泌不足.
- 黄素,源自长,表现出潜在的抗糖尿病特性.
- 在T2DM中血糖水平升高需要有效的治疗干预措施.
研究的目的:
- 评估黄素在改善T2DM患者的血糖控制和代谢参数方面的疗效.
- 评估黄素对胰岛素抵抗,β细胞功能和体重的影响.
- 确定黄素干预T2DM患者的安全概况.
主要方法:
- 一个为期12个月的随机,双盲,安慰剂对照试验,涉及272名T2DM患者.
- 参与者每天接受1500毫克的黄素或安慰剂.
- 关键的代谢标志物包括禁食血葡萄糖,HbA1c,HOMA-β,HOMA-IR,阿迪波涅克丁,丁,体重和BMI都被监测.
主要成果:
- 与安慰剂相比,黄素治疗显著降低了禁食血糖和HbA1c (P<0.05).
- 在黄素组中观察到β细胞功能改善 (HOMA-β增加) 和胰岛素抵抗降低 (HOMA-IR降低) (分别P<0.01和P<0.001).
- 库尔库明的干预导致体重指数 (P<0.001) 显著降低,瘦素,和增加阿迪波内克丁水平.
结论:
- 经过12个月的黄素干预,在T2DM患者中显示出显著的降糖效应.
- 库尔库明治疗改善了β细胞功能,胰岛素抵抗和体重,副作用最小.
- 黄素可能是2型糖尿病肥胖患者的有益治疗选择.
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