非编码RNA作为三阴性乳腺癌中放射反应调节剂:系统性审查
Maria Vitoria Tofolo1, Fernanda Costa Brandão Berti1, Emanuelle Nunes-Souza1
1Research Institute Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Av. Silva Jardim, 1632, Curitiba, 80250-060, Brazil.
Journal of biomedical science
|October 1, 2024
概括
非编码RNAs (ncRNAs) 在三阴性乳腺癌 (TNBC) 放射电阻中发挥着关键作用. 了解这些ncRNA可以帮助预测治疗反应,并改善接受放射治疗 (RdT) 的TNBC患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 三重阴性乳腺癌 (TNBC) 是高度侵入性的,预后不佳.
- 放射疗法 (RdT) 是一种常见的治疗方法,但放射电阻是一个主要的挑战.
- 非编码RNAs (ncRNAs) 参与调节基因表达和治疗耐药性.
研究的目的:
- 系统地审查ncRNAs在TNBC中调节放射反应中的作用.
- 在TNBC中识别与辐射敏感性或电阻相关的特定ncRNA.
- 探索ncRNAs影响TNBC对RdT.反应的分子机制.
主要方法:
- 系统的文献审查遵循PRISMA指南.
- 在四个数据库中使用选定的关键字进行全面搜索.
- 包含/排除标准适用于37篇原创研究文章 (至2023年10月).
主要成果:
- 33种不同的ncRNAs (lncRNAs,miRNAs,circRNAs) 被确定与TNBC中的辐射反应有关.
- 这些ncRNAs影响关键的分子机制,包括细胞死亡调节和DNA损伤修复.
- 一个复杂的ncRNAs网络显著调节TNBC对RdT的响应能力.
结论:
- ncRNAs是三阴性乳腺癌中放射电阻的关键调节者.
- 了解ncRNA网络为识别RdT不响应者提供了潜在的潜力.
- 向ncRNAs可能会改善TNBC患者的治疗策略和生存结果.
相关概念视频
01:23Types of RNA
63.3K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
63.3K
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
01:31Transducer Mechanism: Nuclear Receptors
1.3K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.3K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
02:15Experimental RNAi
6.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
01:23Regulation of Expression at Multiple Steps
875
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
875