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微生物衍生抗氧化剂对生长表现,肝氧化应激,线粒体功能和断母猪细胞亡的影响
Chengbing Yu1, Yuxiao Luo1, Cheng Shen1
1Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Journal of animal science and biotechnology
|October 1, 2024
概括
微生物衍生的抗氧化剂 (MA) 通过减少氧化应激和改善线粒体功能来增强断奶小猪的生长和肝脏健康. 补充MA有效地扭转了断奶引起的损害,促进了整体健康.
科学领域:
- 动物科学动物科学
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
背景情况:
- 断奶会诱导 redox dyshomeostasis 和肝氧化损伤 在小猪.
- 微生物衍生的抗氧化剂 (MA) 显示出减轻氧化应激的潜力.
研究的目的:
- 在断奶后调查肝脏氧化还原系统和线粒体功能.
- 评估MA对断奶小猪生长表现和肝脏健康的影响.
主要方法:
- 进行了两项实验,对21天后断奶的小猪进行了试验.
- 实验1涉及在断奶后的不同时间点屠宰小猪.
- 实验2将MA测量与盐水对照组进行了比较.
主要成果:
- 断奶导致生长抑制和肝损伤,增加活性氧物种 (ROS) 和促进亡.
- 补充MA改善了平均每日增益和料摄入量.
- 马减少了肝脏ROS,氧化损伤标志物 (MDA,8-OHdG) 和亡,同时增强了线粒体功能.
结论:
- MA提高了生长性能,并逆转了断奶引起的氧化损伤和小猪的线粒体功能障碍.
- 在断奶小猪中,MA显示出保持肝脏健康的前景.
- 这些发现为人类肝病研究提供了洞察力.
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