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优化目标和隔膜配置,以及使用在肺瘤的立体性废除性放射治疗中使用连续正气道压力的剂量测量效益

Jung Bin Park^1,2, Joo Ho Lee^1,2, Ji Hyun Chang^1,2

¹Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.

Radiation oncology journal

|October 2, 2024

概括

持续的正气道压力 (CPAP) 改善了对立体性废除性辐射疗法 (SABR) 的肺瘤向. 这种方法增强了肺部扩张并减少了规划目标体积的不确定性,提供了剂量测量优势,具有良好的耐受性.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
肺部病理学肺部病理学

背景情况:

精确的目标划分对于肺部立体性废除性辐射疗法 (SABR) 是至关重要的.
呼吸运动显著影响治疗精度,需要有效的运动管理策略.
持续正气道压力 (CPAP) 有可能改善肺部扩张并减少运动器件.

研究的目的:

为了评估CPAP在SABR过程中促进肺瘤的目标划定的影响.
评估CPAP在肺扩张和呼吸运动管理中的作用,对于接受肺SABR的患者.
为了确定CPAP在肺部SABR中使用的剂量测量益处和安全概况.

主要方法:

预期单一机构试验,涉及接受SABR治疗的原发性肺癌或转移患者.
四维计算机断层扫描 (4D CT) 模拟用CPAP和没有CPAP进行.
分析包括测量超低端距离,计划目标体积 (PTV) 与隔膜重叠,以及剂量计参数.

主要成果:

CPAP显著增加了瘤和隔膜之间的超低层距离,对于与瘤不相邻的瘤而言.
对于与隔膜相邻的瘤,CPAP显著降低了PTV重叠.
CPAP导致PTV体积显著减少,剂量参数得到改善,没有任何不良事件超过2级.

结论:

通过增强肺扩张和控制呼吸运动,CPAP显著提高了肺SABR中的目标划界精度.
使用CPAP提供了剂量测量优势,并显示出有利的安全性和耐受性.
CPAP代表了肺SABR中呼吸运动管理的有前途的新策略,需要进一步研究.

关键词:

持续的正气道压力持续的正气道压力图像细分图像细分图像细分肺部瘤是什么肺部瘤放射疗法是一种放射治疗.呼吸系统成像技术的成像技术.立体性身体放射治疗立体性身体放射治疗

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