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皮肤导向放射治疗用于原发性皮肤T细胞淋巴瘤

Ha Un Kim¹, Yeon Joo Kim¹, Mi Woo Lee²

¹Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Radiation oncology journal

|October 2, 2024

概括

皮肤导向放射治疗 (RT) 有效控制具有低毒性的原发性皮肤T细胞淋巴瘤 (CTCL). 这种治疗显示出高响应率和局部疾病可控的副作用.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
辐射瘤学辐射瘤学

背景情况:

初级皮肤T细胞淋巴瘤 (CTCL) 是一组多样化的非霍奇金淋巴瘤.
皮肤导向放射治疗 (RT) 是局部CTCL的主要治疗方式.
评估RT疗效和毒性对于优化患者的治疗结果至关重要.

研究的目的:

评估皮肤导向RT在治疗原发性皮肤T细胞淋巴瘤 (CTCL) 的有效性和安全性.
在早期和高级阶段的CTCL中比较不同RT方法的结果.

主要方法:

以皮肤为导向的RT治疗的57个CTCL病变的回顾性分析 (2000-2022年).
病变分为:早期局部RT,晚期局部RT和晚期全皮电子束疗法 (TSEBT).
评估的结果包括应答率,复发模式和局部进展.

主要成果:

观察到的高完全响应率:95.5% (早期局部RT),70.8% (高级局部RT),90.9% (高级TSEBT).
在29.2% (高级局部RT) 和63.6% (高级TSEBT) 的病例中,发现了局部复发,主要是Mycosis Fungoides (MF).
急性毒性主要是1-2级,没有严重事件;RT剂量与MF的局部进展无关.

结论:

面向皮肤的RT在实现CTCL局部控制方面表现出显著的有效性.
治疗耐受性良好,有良好的毒性概况.
RT是治疗T细胞淋巴瘤的一种有价值的治疗选择.

关键词:

淋巴瘤是一种淋巴瘤.放射疗法是一种放射治疗.皮肤皮肤皮肤皮肤这就是T细胞.

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