合格-一项回顾性质量控制研究,评估儿科长轴视野低剂量FDG-PET/CT
Sabrina Honoré d'Este1, Flemming Littrup Andersen1, Christina Schulze1
1Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Frontiers in nuclear medicine
|October 2, 2024
概括
儿科PET扫描可以使用半个标记剂量 (1.5 MBq/kg 2-[18F]FDG) 和更短的扫描时间在LAFOV PET/CT. 这样可以保持诊断的准确性,同时减少儿童的辐射暴露.
科学领域:
- 核医学是一种核医学.
- 放射性成像学成像技术
- 儿科瘤学 儿科瘤学
背景情况:
- 儿科患者面临更高的风险从辐射诱导的恶性瘤由于他们的生理发展和更长的预期寿命.
- 优化正子发射断层扫描 (PET) 协议在儿科核医学中至关重要,以尽量减少辐射暴露.
- 长轴视野 (LAFOV) PET/CT提供了更高的灵敏度,使得可减少标记剂剂量.
研究的目的:
- 在儿科患者中使用Biograph Vision Quadra LAFOV PET/CT扫描仪评估降低2[18F]FDG追踪活性 (1.5 MBq/kg) 的临床性能.
- 评估减少的追踪器活性和获取时间对图像质量和儿童病变检测的影响.
主要方法:
- 50名儿科患者接受了全身PET/CT,使用1.5MBq/kg的2-[18F]FDG与标准儿科协议.
- 创建了多个图像重建,采用不同的采集时间,过器和代设置.
- 图像噪声在肝脏感兴趣区域使用方差系数 (COV) 来量化,核医学医生审查了病变检测.
主要成果:
- 大多数重建实现了可接受的图像噪声水平 (COV平均值≤0.15).
- 图像噪声通过更长的采集时间,更少的代和2毫米高斯波器显著改善.
- 损伤检测显示显著改善,与150s相比,获得时间为300s和600s;99%的恶性病变在150s和100%在300s (vs. 600s) 中被检测出来.
结论:
- 一个2-[18F]FDG剂量为1.5MBq/kg,在LAFOV PET/CT上获得5分钟的时间,对于儿科患者来说是临床可行的.
- 这种优化的协议保持了诊断性能,同时显著减少了辐射暴露.
- 益处包括增加患者舒适度,减少对镇静剂的需要,以及个性化扫描协议.
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