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Updated: Jun 11, 2025

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

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选择性抑制癌细胞迁移使用对pH响应的核基基修饰DNA吸收剂

Yuyuan Chen1, Kunihiko Morihiro1, Yui Nemoto1

  • 1Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan morihiro@chembio.t.u-tokyo.ac.jp okamoto@chembio.t.u-tokyo.ac.jp.

Chemical science
|October 2, 2024
PubMed
概括

研究人员开发了一种简单的pH响应的DNA吸收体,使用一种非自然的核基来向癌细胞. 这种新型的阿普坦酶选择性地结合c-Met,抑制癌细胞迁移,并提供了一种新的治疗策略.

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Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor09:33

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