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Updated: Jun 11, 2025

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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非编码基因组内的变异影响了人类白细胞抗原基因的遗传和表观遗传调节

Thilona Arumugam1, Theolan Adimulam1, Anmol Gokul1

  • 1School of Laboratory Medicine, Medical Science, University of KwaZulu-Natal, Durban, South Africa.

Frontiers in immunology
|October 2, 2024
PubMed
概括

非编码的遗传变异和表观遗传因素显著影响人类白细胞抗原 (HLA) 基因表达,影响免疫反应和疾病易感性. 了解这些调节机制对于开发新的诊断和治疗方法至关重要.

关键词:
通过DNA甲基化.表观遗传学是指表观遗传学.人类白细胞抗原系统 (HLA)主要组织相容性复合体 (MHC)这是一个微型RNA.没有编码的RNA.单核酸多态 (单核酸多态,简称SNP)

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