在接种SARS-CoV-2疫苗后,B细胞的强大和持续的反应决定了对SARS-CoV-2感染的保护
Joanne Byrne1,2, Lili Gu1, Alejandro Garcia-Leon1
1Centre for Experimental Pathogen Host Research (CEPHR), University College Dublin, Dublin, Ireland.
Frontiers in immunology
|October 2, 2024
概括
免疫记忆B细胞,而不是抗体或T细胞反应,预测在接种第三剂疫苗后对严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染的保护. 更高的B细胞记忆频率与感染风险降低相关.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 对抗SARS-CoV-2感染的保护的明确免疫相关性仍未确定.
- 了解疫苗接种后的免疫反应对于管理流行病至关重要.
研究的目的:
- 为了探索第三剂SARS-CoV-2疫苗接种后的抗体,B细胞和T细胞反应.
- 确定这些免疫反应与发生的SARS-CoV-2感染之间的关系.
主要方法:
- 对接受第三剂SARS-CoV-2疫苗的成年人进行前性队列研究.
- 测量血抗体,B细胞和T细胞的反应.
- 自我报告发生的SARS-CoV-2感染和比较分析.
主要成果:
- 抗体和B细胞反应在第三剂疫苗接种后增加,持续了10个月.
- 在没有发展SARS-CoV-2感染的参与者中观察到更高的受体结合域 (RBD) 记忆B细胞频率.
- 在受感染和未受感染的参与者之间,没有发现抗体标位或T细胞反应的显著差异.
结论:
- 强大的抗体和B细胞反应在第三次接种疫苗后的10个月内持续存在.
- 记忆B细胞频率,而不是抗体标位或T细胞反应,可以预测对SARS-CoV-2感染的保护.
- 记忆B细胞被确定为对抗SARS-CoV-2的保护的相关物.
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