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Updated: Jul 17, 2026

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
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从单细胞到空间转录组学:解码质瘤干细胞利基及其临床影响

Lei Cao1, Xu Lu1, Xia Wang1

  • 1Department of Oncology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China.

Frontiers in immunology
|October 2, 2024
PubMed
概括

这项研究确定了结质瘤干细胞 (GSC) 和它们与髓状细胞衍生抑制细胞 (MDSC) 的相互作用,开发了一种新的预后特征 (GSCS),以改善结质瘤患者的治疗结果. 图巴1C基因显示了治疗潜力.

关键词:
在TUBA1C中.癌症干细胞是癌症干细胞.预后签名 预测签名一个单细胞RNA测序.空间转录学 空间转录学

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Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...