在没有其他系统性自身免疫性类风湿性疾病的抗脂抗体阳性患者中,细胞结合补充激活产品
Doruk Erkan1,2, Joann Vega1, Tyler O'Malley3
1Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, New York, NY, United States.
Frontiers in immunology
|October 2, 2024
概括
补充激活标记物,细胞结合的补充激活产品 (CB-CAPs),在抗脂抗体 (aPL) 阳性患者中比C3/C4水平更频繁异常. 在这些患者中,CB-CAPs可能有助于评估疾病活性和血栓形成风险.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 血液学 血液学 血液学
背景情况:
- 抗脂抗体 (aPL) 与血栓形成和妊娠并发症有关.
- 补充系统的激活与抗脂综合征 (APS) 病原发生有关.
- 标准补充水平 (C3/C4) 可能不完全反映aPL阳性个体的补充激活.
研究的目的:
- 在没有其他系统性自身免疫性类风湿性疾病的aPL阳性患者中分析补充剂激活.
- 评估细胞结合补充激活产品 (CB-CAPs) 包括B淋巴细胞 (BC4d),红细胞 (EC4d) 和血小板 (PC4d) 与C3/C4水平的效用.
- 为了将补充激活与aPL概况和临床表现相关联.
主要方法:
- 在持久性aPL阳性患者中分析C3/C4和CB-CAP (BC4d,EC4d,PC4d).
- 招募患有或没有aPL相关的临床表现的患者 (血栓性APS,微血管性APS,产科APS,血小板减少,血液溶解性贫血).
- 基线血液采集和临床数据;6个月或12个月后的子组随访.
主要成果:
- 在基线时,13%的患者的C3/C4水平下降,而24-38%的患者的CB-CAPs水平升高 (BC4d,EC4d,PC4d).
- 较高的CB-CAP和较低的C3/C4与三倍aPL或孤立狼抗凝剂阳性相关.
- 与血栓性APS相比,在患有微血管APS,血栓性cytopenia或血液溶解性贫血的患者中观察到更高的EC4d和PC4d阳性率.
结论:
- 在aPL阳性患者中补充剂的激活是异质的,受aPL形状和临床表型的影响.
- 细胞结合补充激活产品 (CB-CAP) 在aPL阳性患者中比C3/C4水平更频繁异常.
- 在评估aPL阳性个体的疾病活性和血栓形成风险方面,CB-CAPs可能发挥着宝贵的作用.
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