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周围淋巴细胞与单细胞的比率作为急性缺血性中风患者早期神经系统恶化的预测因素

Liying Sun¹, Xuhui Ye¹, Junping Yu¹

¹Intensive Care Unit, Shidong Hospital, Shanghai, People's Republic of China.

International journal of general medicine

|October 2, 2024

概括

低淋巴细胞与单细胞比率 (LMR) 与急性缺血性中风 (AIS) 患者的早期神经系统恶化 (END) 有关. 较低的LMR (<3.24) 独立地预测END,突出其临床意义.

科学领域:

神经学神经学
血液学血液学血液学
临床医学临床医学

背景情况:

淋巴细胞与单细胞的比率 (LMR) 是急性缺血性中风 (AIS) 的潜在预后标志物.
早期神经系统恶化 (END) 是AIS患者的一个关键并发症,影响结果.
在AIS中,LMR和END之间的具体关系尚不清楚.

研究的目的:

调查LMR与AIS患者的END发生之间的关联.
确定LMR是否是AIS中END的独立预测因素.

主要方法:

一项对202名AIS患者的回顾性研究.
通过ROC曲线分析,患者被分为低LMR (<3.24) 和高LMR (≥3.24) 组.
采用多变量逻辑回归来确定END的独立预测因素,定义为NIHSS在住院日0和5之间增加≥4点.

主要成果:

与高LMR组 (15.89%,p < 0.001) 相比,在低LMR组 (41.05%) 中,END的发生频率更高.
独立预测END的预测因素包括年龄,心脏病发作量,中性粒细胞数量和LMR.
较低的LMR (LMR<3.24) 与END有显著的关联 (OR=2.49,p=0.018).

结论:

入院时的周围LMR水平与AIS患者的END显著相关.
较低的LMR (<3.24) 作为AIS中END的独立预测因素.

关键词:

急性缺血性中风是急性缺血性中风.早期的神经系统恶化.淋巴细胞与单细胞的比率.美国国家卫生研究院的中风大小.

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