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相关概念视频

Protein Complex Assembly02:41

Protein Complex Assembly

10.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
10.6K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Nucleic Acid Structure01:25

Nucleic Acid Structure

6.0K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.0K
DNA as a Genetic Template02:05

DNA as a Genetic Template

21.8K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
21.8K
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

14.0K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
14.0K

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相关实验视频

Updated: Jun 11, 2025

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

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在DNA单核酸自组合的基研究.

Mattia Trapella1, Tommaso Bellini2, Cristiano De Michele3

  • 1Dipartimento di Fisica e Geologia, Università di Perugia, Perugia, Italy.

The Journal of chemical physics
|October 2, 2024
PubMed
概括

像DNA和RNA这样的核酸通过沃森-克里克配对和堆叠相互作用自我组装成有序的液晶相. 计算机模拟证实了这种行为,强调了这些分子相互作用的重要性.

科学领域:

  • 生物物理学的生物物理.
  • 材料科学 材料科学 材料科学
  • 计算化学计算化学

背景情况:

  • DNA和RNA单核酸缩溶液表现出自我组装和远程排序.
  • 这些分子形成沃森-克里克对,堆叠成柱子,组织成柱状液晶相.

研究的目的:

  • 为了数值地研究核酸单核酸的相位行为.
  • 使用粗粒度方法建模核酸自我组装.

主要方法:

  • 利用一种极其粗粒度的模型,将核酸表示为具有吸引力的位置的半盘状多面体.
  • 采用了从计算机图形算法中改编的蒙特卡洛模拟.
  • 模拟的相互作用模仿核酸配对和堆叠.

主要成果:

  • 该模型成功地复制了核酸单核酸的实验观察到的相位行为.
  • 证实了柱状液晶相形成的情况.
  • 该研究强调了组合配对和堆叠相互作用的关键作用.

结论:

  • 粗粒度模型有效地捕捉了核酸自我组装的基本物理.
  • 液晶相的形成是由特定的分子相互作用驱动的.

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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

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  • 这项工作为理解核酸自我组织提供了一个计算框架.