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Updated: Jun 11, 2025

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
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以化物为基础的I类选择性HDAC抑制剂在抗固体癌细胞中完全逆转化学抵抗,并协同作用

Fabian B Kraft1, Lukas Biermann2, Linda Schäker-Hübner1

  • 1Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

Journal of medicinal chemistry
|October 2, 2024
PubMed
概括

新的基于peptoid的基因组脱乙酶抑制剂 (HDACi) 对癌细胞表现出强烈的活性. 化合物5和6可以逆转西斯普拉丁耐药性,提高化疗疗效,为药物开发提供有前途的线索.

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