跨性别男性开始性别确认激素治疗中的骨代谢的短期变化:系统性审查和元分析
Daniele Tienforti1, Lorenzo Marinelli2,3, Jeroen Vervalcke3
1Andrology Unit, Department of Clinical Medicine, Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy. danieletienforti@gmail.com.
Calcified tissue international
|October 2, 2024
概括
跨性别男性的丸激素治疗在短期内似乎对骨健康是安全的,没有观察到骨密度或关键矿物质的显著变化. 增加P1NP标志物表明潜在的积极合成代谢效应.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 跨性别者健康 跨性别者健康
背景情况:
- 变性男性可能会使用丸激素疗法来治疗男性化.
- 在这个人群中,对骨健康的短期影响需要进一步阐明.
研究的目的:
- 系统地审查和元分析在开始丸激素治疗的跨性别男性骨代谢的短期变化.
- 为了评估骨矿物质密度和骨周转指标的变化.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane图书馆进行系统搜索.
- 纳入了14项涉及1484名跨性别男性的研究,分析了12个月和24个月的数据.
- 随机效应模型用于对骨矿物质密度,,酸盐,25OHD,PTH,P1NP,BAP,骨和CTx进行元分析.
主要成果:
- 腰椎,部,大腿部和整个身体的骨矿物质密度 (BMD) 没有显著变化.
- ,酸盐,25-氧维生素D (25OHD) 和副甲状腺激素 (PTH) 水平保持稳定.
- 在12个月的丸激素治疗 (SMD 0.61mcg/l) 后,Procollagen Type 1 N-terminal Propeptide (P1NP) 显著增加.
结论:
- 短期丸激素治疗 (12和24个月) 似乎不会对跨性别男性的骨健康产生负面影响.
- 12个月后P1NP的显著增加表明的潜在短期合成代谢作用.
- 进一步的研究可能会探索长期的骨健康结果和P1NP升高的临床意义.
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