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肺部神经内分泌新生瘤的诊断问题

Atsuko Kasajima¹, Günter Klöppel²

¹Department of Pathology, TUM School of Medicine and Health, Trogerstr. 18, 81675, Munich, Germany. atsuko.kasajima@tum.de.

Pathologie (Heidelberg, Germany)

|October 2, 2024

概括

支气管肺神经内分泌瘤 (BP-NENs) 的分类需要更新的标准. 这篇评论探讨了使用Ki-67指数来更好地分类这些肺瘤.

科学领域:

在瘤学瘤学.
肺部病理学肺部病理学
病理学病理学病理学

背景情况:

支气管肺神经内分泌瘤 (BP-NENs) 占所有神经内分泌瘤 (NENs) 的约30%.
虽然BP-NEN和胃肠道胰腺NEN (GEP-NEN) 具有共同的特征,但在分类和术语上有所不同.
支气管肺神经内分泌瘤 (BP-NETs) 的传统分类为典型的癌 (TC) 和非典型的癌 (AC) 缺乏用于GEP-NENs的Ki-67指数.

研究的目的:

审查目前的BP-NEN分类,并突出与GEP-NEN分级的差异.
讨论Ki-67指数在完善BP-NETs/carcinoids分类中的潜在作用.
解决缺少一个定义类别的高度分化的NENs与高的线粒细胞计数 (相当于GEP-NENs中的G3).

主要方法:

审查现有的文献和世卫组织对NENs的分类.
对BP-NEN和GEP-NEN分类系统的比较分析.
讨论Ki-67指数整合的影响.

主要成果:

世界卫生组织 (WHO) 2022年分类引入了NET G1和G2作为TC和AC的同义词.
与GEP-NEN不同的是,Ki-67指数没有正式纳入BP-NEN的分类标准.
目前,对于支气管肺NENs来说,缺乏对高等级,分化良好的NENs (NET G3等效) 的定义类别.

结论:

目前的BP-NEN分类需要改进,以与其他NEN使用的分级系统保持一致.
纳入Ki-67指数对于准确的BP-NET分级和预测至关重要.
标准化分类,包括Ki-67指数,将改善支气管肺神经内分泌瘤的管理和理解.

关键词:

癌类动物的癌类动物.在 Ki6767 的位置上.肺肺肺肺肺肺肺神经内分泌瘤是一个神经内分泌瘤.肺部肺部肺部肺部世界卫生组织的分类.

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