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用于治疗桃体切除术后出血的雾化甘酸:一个系统性审查和元分析
Abdullah S Alghamdi1, Ghaydaa S Hazzazi2, Mohammad H Shaheen2
1Department of Otorhinolaryngology, Head and Neck Surgery, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia. asdnjm@hotmail.com.
概括
雾化甘酸 (TXA) 有效治疗桃体切除术后出血 (PTB),显著降低了重新手术的发生率. 这一系统审查证实了其在紧急情况下的安全性和有效性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 桃体切除术后出血 (PTB) 是一种常见的并发症,需要急诊室 (ED) 的访问.
- 关于用于治疗PTB的雾化酸 (TXA) 的数据有限且相互矛盾.
研究的目的:
- 进行第一个关于 nebulized TXA 治疗 PTB 的疗效和安全性的系统审查.
- 综合现有的关于在管理PTB中雾化TXA的文献.
主要方法:
- 在2024年7月1日之前,对六个数据库进行系统的文献搜索.
- 使用经过验证的工具进行包含的研究的质量评估.
- 使用随机效应模型对重新操作率 (比例或RR与95%CI) 的元分析.
主要成果:
- 分析了9项研究 (2个案例报告,4个案例系列,3个回顾性比较研究).
- 用 nebulized TXA 治疗的 PTB 的综合复发率为 0.27 (95% CI: 0.08-0.5).
- 与没有TXA相比,雾化TXA显著降低了重新操作率 (RR = 0.55,95%CI [0.39-0.77],p < 0.001).
结论:
- 雾化TXA在ED环境中证明了在实现PTB血液静止方面的安全性和高效性.
- 它大大减少了对控制PTB的重新操作的需求.
- 建议进一步进行高质量的研究来证实这些发现.
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