在14个人口群体中,中风前后认知衰退的轨迹
Jessica W Lo1, John D Crawford1, Darren M Lipnicki1
1Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
JAMA network open
|October 2, 2024
概括
脑卒中显著影响认知功能,导致即时衰退,并加速老年人的长期认知障碍. 在幸存者中,中风前的认知轨迹与没有中风的人没有区别.
科学领域:
- 神经学 神经学
- 认知科学 认知科学
- 流行病学 流行病学
背景情况:
- 脑卒中后的认知障碍是一个重大的问题,但与脑卒中前的功能相对而言,精确的认知轨迹仍然不太清楚.
- 了解第一次中风后的认知变化对于患者护理和干预策略至关重要.
研究的目的:
- 绘制第一次中风前后的认知轨迹,检查全球认知和四个特定领域.
- 将中风幸存者的认知轨迹与没有中风的个人进行比较.
主要方法:
- 利用了来自14项国际基于人口的队列研究 (1993-2019) 的协调,聚合数据.
- 采用线性混合效应模型分析20,860名老年人的认知轨迹,调整人口和血管风险因素.
- 定义主要结果为全球认知,语言,记忆,处理速度和执行功能的平均得分.
主要成果:
- 发生性中风与全球认知 (-0.25 SD) 和所有认知领域的急性下降有关.
- 卒中幸存者在全球认知 (-0.038 SD/年) 和大多数领域中经历了加速的长期认知衰退.
- 在未来中风幸存者和非中风个体之间,在中风前的认知衰退率中没有发现显著差异.
结论:
- 发生性中风与老年人的即时和加快的长期认知衰退有关.
- 在中风前的认知轨迹似乎不会在将经历中风的人和不会经历中风的人之间有所不同.
- 这些发现强调了中风对认知的影响深远,并强调了需要进行中风后认知监测的必要性.
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