八周补充Bifidobacterium lactis HN019和功能性便秘:一个随机临床试验
Jing Cheng1, Carl Gao2, Reeta Ala-Jaakkola1
1Department of Health, International Flavors & Fragrances, Kantvik, Finland.
这项研究发现,与安慰剂相比,Bifidobacterium animalis subsp lactis HN019在功能性便秘的成年人中没有显著改善完全自发性肠道排便 (CSBM). 需要进一步的研究来探索益生菌对便秘的疗效.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 临床营养学 临床营养学
背景情况:
- 益生菌补充剂通常被建议用于改善肠道排便.
- 然而,来自大规模,精心设计的研究的强有力的临床证据是有限的.
- 功能性便秘影响着相当一部分人群,需要有效的干预措施.
研究的目的:
- 评估Bifidobacterium animalis subsp lactis HN019在改善功能性便秘患者完全自发性肠道排便 (CSBMs) 的疗效.
- 评估这种益生菌对各种与肠道功能和肠道健康相关的次要结果的影响.
- 提供关于益生菌用于便秘管理的高质量证据.
主要方法:
- 一个随机的,三重盲目的,安慰剂控制的试验,涉及229名功能性便秘的参与者.
- 参与者每天接受Bifidobacterium animalis subsp lactis HN019或马尔托德素安慰剂,持续8周.
- 主要结局是每周CSBM的变化;次要结局包括便一致性,腹痛,胀气和便分析.
主要成果:
- 在HN019组和安慰剂组之间,每周CSBMs与基线的变化没有显著差异.
- 二次结果,如便一致性,紧张,腹痛和胀气,也没有显示出益生菌干预的显著改善.
- 便分析没有显示出小组之间微生物群组成或其他测量参数的显著变化.
结论:
- 每天服用Bifidobacterium animalis subsp lactis HN019的剂量为4.69 × 10^9 CFU,在增加CSBM方面没有显示出比安慰剂更高的疗效.
- 这项大型,经过良好的临床试验不支持使用这种特定的益生菌来改善功能性便秘的肠道运动.
- 这些发现强调了对益生菌在治疗便秘中的作用进行持续严格研究的必要性.
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