酸治疗长期COVID疲劳和认知功能障碍:一项随机临床试验
Thomas Guttuso1, Jingtao Zhu2, Gregory E Wilding2
1Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Williamsville, New York.
JAMA network open
|October 2, 2024
概括
10-15毫克/天的酸在长期COVID患者中没有改善疲劳或认知功能障碍. 更高的剂量可能需要在未来的随机对照试验 (RCT) 中进行进一步调查.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 神经学后COVID-19状况 (PCC),或长期COVID,显著影响数以百万计的持续疲劳和认知功能障碍.
- 目前神经性PCC的治疗选择有限,缺乏强有力的基于证据的支持.
研究的目的:
- 评估酸在缓解与神经PCC相关的疲劳和认知功能障碍方面的疗效.
- 探索酸在治疗长期COVID症状方面的潜在益处.
主要方法:
- 进行了一项随机,双盲,安慰剂对照试验 (RCT),随后进行了一项开放式剂量确定研究.
- 纳入了COVID-19后持续疲劳或认知功能障碍的参与者.
- 主要结局是联合疲劳严重性度量-7 (FSS-7) 和脑雾严重性度量 (BFSS) 评分的变化.
主要成果:
- 与安慰剂相比,酸 (10-15 mg/d) 在RCT中没有显著改善疲劳或认知功能障碍.
- 在研究期间,没有任何不良事件归因于治疗.
- 剂量确定阶段的初步发现表明,使用更高的酸剂量 (40-45 mg/d) 有潜在的益处.
结论:
- 低剂量酸 (10-15 mg/d) 在治疗神经学PCC相关疲劳和认知功能障碍方面是无效的.
- 需要进一步的RCT来研究更高的酸剂量对神经PCC的疗效.
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