亚托瓦斯塔丁载入的溶解微阵列贴片用于长期起作用的微积分输送:纳米粒子和微粒子药物配方的比较
Yara A Naser1, Lalitkumar K Vora1, Ismaiel A Tekko1,2
1School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, U.K.
ACS applied materials & interfaces
|October 2, 2024
概括
这项研究开发了溶解微阵列贴片 (D-MAPs) 用于长效阿托瓦斯塔丁 (ATR) 输送,为高脂血症管理提供了注射的非侵入性替代方案. 装有微粒的D-MAP成功地在14天内达到治疗性ATR水平.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 延长释放药物配方可以提高患者的服药性,但往往需要注射等侵入性方法.
- 实现持续的药物释放超过24小时的非侵入性仍然是一个挑战,特别是对于患有针恐惧症的患者来说.
研究的目的:
- 开发和评估装有阿托瓦斯塔丁 (ATR) 微粒 (MP) 或纳米晶体 (NC) 的新型溶解微阵列贴片 (D-MAP),用于非侵入性,长效的皮内输送.
- 评估D-MAPs作为一种在两周内治疗超脂血症的最小侵入性替代品的潜力.
主要方法:
- 在ATR上装载的MP-D-MAP和NC-D-MAP的制造.
- 在体外皮肤沉积的研究量化ATR释放超过24小时.
- 在Sprague-Dawley大鼠体内的药理动力学研究,以评估14天内的ATR输送.
主要成果:
- 与NC-D-MAP (2.4 mg/patch) 相比,MP-D-MAP显示出更高的ATR负载 (5.15 mg/patch),而不是NC-D-MAP (2.4 mg/patch).
- MP-D-MAPs在24小时内表现出优异的皮肤递送 (2.0 mg/补丁,38.76%负载) 与NC-D-MAPs (0.89 mg/补丁,38.42%负载) 相比.
- 在体内研究证实了MP-D-MAP单次应用后14天的持续治疗ATR度 (>20 ng/mL).
结论:
- 装有ATR的MP-D-MAP可在一次应用后长达14天的时间内提供有效的,长效的透皮药物输送.
- D-MAP技术,特别是微粒子加载技术,代表了阿托瓦斯塔丁输送的有希望的,最少侵入性的替代方案.
- 这种创新方法有可能显著改善患者的服从性和高脂血症管理中的治疗结果.
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