连续的早期病毒感染调节了微生物群和适应性免疫反应,以对系统和粘膜疫苗接种
Yuhao Li1, Jerome M Molleston2, Crystal Lovato1
1Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.
早期的病毒感染显著改变了小鼠的免疫发育,影响了它们对疫苗的反应. 这些暴露减少了SARS-CoV-2疫苗接种后的抗体产生,这表明以前的感染可能会降低疫苗的疗效.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 病毒学 病毒学
背景情况:
- 微生物暴露组对宿主免疫系统的发展和对感染和疫苗的反应产生了重大影响.
- 了解早期暴露对免疫成熟的影响对于预测疫苗疗效至关重要.
研究的目的:
- 研究如何连续的早期病毒暴露会影响小鼠免疫系统的发育.
- 确定这些暴露对后续免疫反应和针对SARS-CoV-2的疫苗疗效的影响.
主要方法:
- 新生小鼠被连续接种了六种不同的病毒病原体.
- 在SARS-CoV-2疫苗接种之前和之后 (肌内和鼻内) 分析了免疫细胞群,细胞因子水平和抗体反应.
- 还评估了肠道微生物群组成的变化.
主要成果:
- 连续的病毒感染导致循环白细胞和组织居民免疫细胞的显著改变.
- 在血清细胞因子概况和总抗体水平上观察到明显的变化.
- 尽管疫苗接种后系统性免疫激活和T细胞反应增加,但小鼠表现出疫苗诱导的抗体产生减少.
- 病毒暴露调节了肠道微生物群的组成.
结论:
- 早期的病毒暴露可以深刻地改变小鼠的免疫发育和功能.
- 这些暴露足以损害对疫苗接种的抗体反应,即使增强了T细胞激活.
- 以前的微生物暴露,包括病毒感染,可能是影响疫苗有效性的关键因素.
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