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血开始性病毒的大量扩散与马卡卡莱奥尼尼的SIV病原体有关

Yanpeng Li¹, Tian-Zhang Song², Le Cao¹

¹Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Science advances

|October 2, 2024

概括

中类似免疫缺陷病毒 (SIV) 感染导致血中开始性病毒的显著扩散. 这些病毒变化与炎症和疾病进展相关,突出显示了它们在SIV病变发生过程中的作用.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
灵长类动物模型

背景情况:

人类免疫缺陷病毒-1 (HIV-1) 感染会破坏宿主-微生物平衡.
血开始性病毒在艾滋病毒/猿类免疫缺陷病毒 (SIV) 发病过程中的作用尚未得到充分研究.

研究的目的:

在感染SIV的模型中研究血病毒组,炎症和疾病标志物的纵向变化.
了解开始性病毒和SIV感染之间的动态相互作用.

主要方法:

在SIV感染的*Macaca leonina*中,血病毒组的纵向分析.
测量炎症标志物和疾病指标 (例如,D-二次体,CD4+ T细胞计数).
生物信息注释灵长类动物的anellovirus序列.

主要成果:

在SIV感染的慢性阶段观察到血 *Anelloviridae*, *Parvoviridae*和 *Circoviridae*的显著扩张.
*Anelloviridae*的丰度与CD4+T细胞计数正相关,与SIV负相关.
其他开始性病毒与CD4+T细胞计数和SIV负载呈现逆相关性.
抗逆转录病毒治疗对开始性病毒扩散的影响有限.

结论:

在SIV感染期间,共生病毒在血中经历显著扩张.
不同的开始性病毒家族与宿主免疫状况和病毒载荷具有明显的相关性.
开始性病毒在SIV病原发生过程中起到不同的作用,需要进一步研究.

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