卫生保健相关感染预防 (CLEAN-IT):多中心集群随机交叉开放标签试验的协议
Bruno Martins Tomazini1,2,3, Thabata Silva Veiga1, Renato Hideo Nakagawa Santos1
1HCor Research Institute, HCor-Hospital do Coração - São Paulo (SP), Brazil.
Critical care science
|October 2, 2024
概括
每天用赫西丁二甲酸洗可能会减少重症患者的与医疗保健相关的感染. 在CLEAN-IT试验中,将素浴与标准的肥和水进行比较,以评估其在预防设备相关感染方面的有效性.
科学领域:
- 传染病流行病学 传染病流行病学
- 临界护理医学 临界护理医学
- 抗微生物药物管理委员会
背景情况:
- 危急病患者面临高风险的医疗保健相关感染 (HAI) 从设备,如中央线路,尿导管和呼吸机.
- 每天用赫西丁二甲酸盐 (CHG) 洗被探索以减少重症监护室 (ICU) 的HAI.
- 在预防所有与设备相关的HAI方面,CHG浴的有效性仍然不确定.
研究的目的:
- 评估每天的赫西丁二甲酸盐洗是否与标准的肥和水洗相比,降低了重症患者的HAI发病率.
- 评估CHG浴对特定HAI,多药耐药病原体率,抗生素使用和患者结局的影响.
主要方法:
- 这项研究是一项名为CLEAN-IT的多中心,开放标签,集群随机交叉试验.
- 成年ICU患者将随机由ICU (集群) 开始CHG洗或肥和水洗.
- 干预期持续3-6个月,交叉之前有一个1个月的洗期.
主要成果:
- 主要结局:与设备相关的医疗保健相关感染的发生率.
- 二次结果:特定的HAI的发病率,多抗药性病原体的发病率,抗生素消耗,ICU/住院时间长度和死亡率.
结论:
- 该CLEAN-IT试验调查了实用和成本效益的干预措施,以降低重症患者中HAI的负担.
- 这些发现将为临床实践提供有关使用CHG浴的信息,以预防ICU中的HAI.
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