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Updated: Jun 24, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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考虑到口腔状状细胞癌中的HPV状况,PD-L1免疫组合化学表达

Raíssa Soares Dos Anjos1, Marianne de Vasconcelos Carvalho1, Rayanna Thayse Florêncio Costa2

  • 1Universidade de Pernambuco - UPE, School of Dentistry, Department of Oral and Maxillofacial Pathology, Recife, PE, Brazil.

Brazilian oral research
|October 2, 2024
PubMed
概括

人类乳头瘤病毒 (HPV) 的存在影响了口腔状细胞癌 (OPSCC) 中的编程细胞死亡-1联体 (PD-L1) 表达. 这一发现对于识别可能受益于免疫疗法治疗的患者至关重要.

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Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...