专家对开始使用生物制剂治疗的患者肺结核感染查的意见
Adiba Sultana1,2, Giovanni Battista Migliori3, Lia D'Ambrosio4
1. University of New South Wales, Sydney, Australia.
概括
生物药物可以增加结核病感染的重新激活风险. 专家建议增加对所有生物制剂的查,但这可能导致对某些药物进行过度查,需要进一步的研究和指导方针的改进.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 生物药物可以导致免疫抑制,增加结核病感染的重新激活风险.
- 结核感染再激活 (TBI) 的风险在不同的生物病原体之间有很大差异.
- 目前对开始生物治疗的患者进行TBI查和治疗的临床实践需要评估.
研究的目的:
- 评估目前对开始生物治疗的患者进行TBI查和治疗的临床实践.
- 了解有关各种生物类的TBI查的专家建议.
主要方法:
- 一份在线问卷被分发给全球结核病网络和相关组织的成员.
- 该调查旨在深入了解TBI查和治疗实践对生物药物患者.
主要成果:
- 与目前的做法相比,受访者主张增加对所有生物制剂的TBI查.
- 观察到高TBI查率,并支持TNF-α抑制剂.
- 对B细胞和T细胞抑制剂的查得到了支持,但对白蛋白抑制剂一般不支持;对TNFα抑制剂的指导意识更高.
结论:
- 受访者表示,即使对于具有低TBI风险的生物药物,他们也倾向于推TBI查,这可能导致过度查和过度治疗.
- 需要对与不同生物制剂相关的特定TBI风险进行研究.
- 应该更新指南,以反映所有生物类的TBI风险的变化范围.
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