癌症免疫疗法试验网络12:Pembrolizumab治疗艾滋病毒相关的卡波西肉瘤
Kathryn Lurain1, Ramya Ramaswami1, Irene Ekwede1
1HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
概括
布罗利祖马布在治疗艾滋病毒感染者的高级卡波西肉瘤 (KS) 中显示出有前途的安全性和有效性. 这种免疫疗法导致了持久的反应和可控的免疫相关不良事件.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 与艾滋病毒相关的卡波西肉瘤 (KS) 仍然是一个重大挑战.
- 了解布罗利祖马布等新型治疗方法的疗效至关重要.
研究的目的:
- 评估pembrolizumab在患有艾滋病毒相关的KS的患者中的安全性和有效性.
- 报告来自癌症免疫疗法试验网络12项研究的卡波西肉瘤队列的结果.
主要方法:
- 一个多中心的第一阶段试验,涉及参与者与艾滋病毒相关的KS.
- 患者接受了每3周内静脉注射200毫克的班布罗利祖马布.
- 主要终点是安全性;次要终点是KS反应.
主要成果:
- 32名与艾滋病毒相关的KS的 cisgender男性被录取.
- 在可评估参与者中观察到62.1%的整体反应率 (ORR).
- 观察到持久反应的高率,估计92.3%的DOR为≥12个月.
结论:
- 布罗利祖马布在与艾滋病毒相关的KS中显示出高持续性反应率.
- 免疫媒介不良事件 (imAEs) 可以通过标准治疗指南进行管理.
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