癌症老年人化学疗法诱导的恶心和吐的严重游戏:随机临床试验的协议
Victoria Loerzel1, Arsham Alamian2, John Clochesy2
1College of Nursing, University of Central Florida, Orlando, FL, United States.
JMIR research protocols
|October 2, 2024
概括
这项研究正在评估一个严的游戏,在家管理 (MAH),以帮助老年人管理化疗诱导的恶心和吐 (CINV) 症状. 该游戏旨在提高自我管理技能,并减少这种脆弱人群的不良治疗效应.
科学领域:
- 老年瘤学 老年瘤学
- 数字健康干预措施 数字健康干预措施
- 症状管理 症状管理
背景情况:
- 接受化疗的老年人面临治疗毒性和不良事件的高风险,如化疗诱导的恶心和吐 (CINV).
- 由于对其有效性的误解,许多老年人对治疗相关症状的自我管理策略没有充分利用.
- 一个新的严的游戏,在家里管理 (MAH),是为了赋予老年人在家里管理CINV的权力.
研究的目的:
- 目标1:评估干预组中CINV严重程度,自我管理行为,功能,生活质量,认知表现和医疗保健利用情况的变化.
- 目标2:通过对照组对初级 (CINV严重程度,医疗保健使用) 和二次结果 (自我管理,功能,生活质量) 的比较来确定许可证持有者的干预措施的有效性.
主要方法:
- 一个纵向随机临床试验,涉及500名接受化疗的老年人 (≥60岁).
- 从基线 (T1) 到化疗治疗周期6 (T6) 的数据收集.
- 纳入标准:新诊断的癌症,中度/高排泄潜力的化疗,2-4周周期,精通英语,电话接入. 排除标准:先前的癌症治疗,<6个月的预期寿命,未经纠正的感觉障碍.
主要成果:
- 研究资助2022年9月,IRB批准2022年10月.
- 截至2023年7月,已有130名参与者报名;报名正在进行中.
- 预计到2027年将全面收集和分析数据.
结论:
- 本研究通过创新的严游戏 (MAH) 调查了老年人中CINV的自我管理.
- 许可证持有人的干预使用模拟和游戏来促进积极学习,并纠正对症状自我管理的不准确看法.
- 如果被证明有效,可能适应其他癌症症状或慢性疾病.
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