城市污水处理厂的菌株级多药耐药病原细菌:传播,来源追踪和演变
Yanmei Zhao1, Lu Fan2, Shu-Hong Gao1
1State Key Laboratory of Urban Water Resource and Environment, School of Civil & Environmental Engineering, Harbin Institute of Technology Shenzhen, Shenzhen 518055, China.
Water research
|October 2, 2024
概括
污水处理厂是病原体的庇护所,一些耐药细菌在治疗后仍然存在. 扩大生物监测对公共卫生和环境安全至关重要.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 废水工程 废水工程
背景情况:
- 污水处理厂 (WWTP) 是病原体的储,对公共健康构成风险.
- 了解WWTP中的病原体起源和传播对于有效控制至关重要.
研究的目的:
- 使用元基因组学识别和跟踪WWTP中的病原体.
- 评估目前针对特定病原体的治疗过程的有效性.
- 为废水生物监测提出改进建议.
主要方法:
- 来自三个全尺度WWTP的样本的元基因组测序.
- 病原体识别和源追踪分析.
- 对不同细菌物种的病原体去除率进行比较.
主要成果:
- 在WWTP中发现了299种病原体.
- 有效地去除了像大肠杆菌这样的标准指标病原体.
- 耐药性病原体 (例如,Pseudomonas aeruginosa,Pseudomonas putida,Aeromonas caviae) 在治疗过程中持续存在.
- 无氧阶段控制了病原体的丰富性,但增加了下游的多样性.
- 病原体的多样性在治疗过程中演变,除了一些上游传播的例外.
结论:
- 目前的生物监测指标可能不足以检测持久性,耐药性病原体.
- 废水处理策略需要优化,以应对新出现的病原体风险.
- 加强监测对于保护环境安全和公共健康至关重要.
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