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用加工的Schisandra Chinensis通过托代谢增强了对大肠炎引起的抑郁症的治疗效果

Jiuba Zhang¹, Ting Gao¹, Gang Chen²

¹College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|October 2, 2024

概括

用加工的奇桑德拉中国 (VSC) 通过恢复肠道微生物群和甲酸代谢,有效地治疗性结肠炎 (UC) 小鼠的抑郁症. 这为UC患者的肠-大脑并发症的管理提供了新的见解.

科学领域:

肠-大脑轴研究研究
炎症性肠病 (IBD) 病理生理学
自然产品治疗药物自然产品治疗药物

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病,其病因尚不清楚,并具有伴随性抑郁症的高发病率.
肠-大脑轴是开发UC相关抑郁症新型治疗策略的关键区域.

研究的目的:

为了研究加工的中国 (VSC) 在慢性UC的小鼠模型中对抑郁行为的治疗效果.
阐明涉及肠道微生物群和托代谢的潜在机制.

主要方法:

在小鼠中使用硫酸德克斯建立了慢性UC模型.
通过组织学分析 (H&E,Alcian蓝),用于屏障完整性的传输电子显微镜 (TEM),细胞因子的ELISA,蛋白质表达的西部涂抹,肠道微生物群的元基因组分析和行为测试 (莫里斯水迷宫,开放场地,强迫游泳,尾部悬浮) 评估治疗效果.
使用UPLC-MS/MS分析血清代谢物,以了解代谢途径的改变.

主要成果:

无论是原始还是VSC治疗都提高了酸受体 (AhR) 的调节,抑制了NF-κB p-p65,减少了炎症,并恢复了肠道屏障和血脑屏障 (BBB) 的完整性.
VSC在改善抑郁行为,改善海马神经元结构和调节肠道微生物群组成方面表现出卓越的有效性.
VSC治疗将托代谢从金氨酸途径转移到5-HT或醇途径,由增加的托和降低的金氨酸/香氨酸水平证明.

结论:

破坏托芬代谢平衡是UC诱导抑郁行为背后的一个关键机制.
加工增强了 Schisandra Chinensis (SC) 调节肠道微生物群和酸盐代谢的能力.
这些发现为UC的肠-大脑并发症管理提供了一种新的治疗方法.

关键词:

抑郁症抑郁症抑郁症这种植物是 Schisandra Chinensis.托芬代谢的代谢方式性结肠炎是一种的加工的加工

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