饮食中产生的抗氧化剂与喘之间的关联:来自2003-2018年NHANES调查和孟德尔随机化分析的见解
Linjie Chen1, Congjie Chen2, Mingyu Lin2
1Institute of Respiratory Diseases, Xiamen Medical College, Xiamen, Fujian Province 361023, PR China; Fujian Provincial Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Xiamen, Fujian Province 361023, PR China; Department of Clinical Medicine, Xiamen Medical College, Xiamen, Fujian Province 361023, PR China.
在观察数据中,饮食中的抗氧化剂,如维生素C,和,与喘风险有负相关性. 然而,门德尔的随机化研究发现,这些抗氧化剂与喘发展之间没有因果关系.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 许多研究表明,饮食中的抗氧化剂与喘之间存在联系.
- 然而,饮食中抗氧化剂和喘之间的确切关系仍在调查中.
研究的目的:
- 为了研究饮食衍生的抗氧化剂和喘之间的联系.
- 使用孟德尔随机化探索潜在的因果关系.
主要方法:
- 利用了2003-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用两个样本的门德尔随机化研究来评估终身循环抗氧化剂水平和喘风险之间的因果关系.
主要成果:
- 喘患者更有可能是年轻女性,吸烟者,收入较低,非西班牙裔黑人,高中教育,BMI>30.
- 饮食中摄入的维生素C,,和综合饮食抗氧化剂指数 (CDAI) 与喘风险有负相关性 (例如,维生素C OR=0.76).
- 在饮食中摄入的维生素C,,和喘风险之间观察到显著的非线性关系;然而,没有通过孟德尔随机化确定因果关系.
结论:
- 一项观察性研究表明,饮食中的维生素C,,,CDAI和喘风险之间存在负相关性.
- 门德尔的随机化分析没有支持饮食衍生的抗氧化剂和喘风险之间的因果关系.
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