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使用不同的实验模型生物选择纳米颗粒的比较毒性评估

Srishti Parashar1, Sheetal Raj1, Priyanka Srivastava1

  • 1Department of Biosciences, Institute of Management Studies Ghaziabad (University Courses Campus), NH09, Adhyatmik Nagar, Ghaziabad, Uttar Pradesh, India.

Journal of pharmacological and toxicological methods
|October 2, 2024
PubMed
概括

过度使用纳米粒子,包括碳纳米管,二氧化,二氧化,氧化,氧化铜和银,导致环境毒性和生物积累. 研究表明,这些纳米粒子在各种模型中诱导DNA损伤,器官毒性和细胞损伤,突显了可持续使用的必要性.

关键词:
另一个替代模型模型.高生产率的NP是NP.在体外试验中.在 Invivo 里面生活.纳米颗粒毒性 纳米颗粒毒性植物模型 植物模型

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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