亚临床动脉样硬化负担和进展对死亡率的影响
Valentin Fuster1, Ana García-Álvarez2, Ana Devesa1
1Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; Mount Sinai Fuster Heart Hospital, New York, New York, USA.
Journal of the American College of Cardiology
|October 2, 2024
概括
亚临床动脉样硬化负担和无症状个体的进展独立预测所有原因的死亡率. 冠状动脉斑块负担 (cPB) 显示出比冠状动脉 (CAC) 评分更强的预测值.
科学领域:
- 心血管医学 心血管医学
- 预防性心脏病学 预防性心脏病学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 动脉样硬化是一种渐进的血管疾病.
- 关于预测无症状个体的动脉样硬化程度和进展的死亡率,特别是动脉疾病的数据有限.
研究的目的:
- 确定亚临床动脉样硬化负担和进展是否独立预测无症状成年人的全因死亡率.
- 为了比较动脉斑块负担 (cPB) 和冠状动脉 (CAC) 评分的预后值.
主要方法:
- 5,716名无症状的美国成年人接受了基线血管超声检测cPB和CT检测CAC.
- 对732名参与者进行了cPB的随访超声波.
- 所有参与者均在12.4年的中位数内对所有原因的死亡率进行了跟踪.
主要成果:
- 基线cPB和CAC得分独立与所有原因死亡率相关.
- 与CAC相比,cPB的预测性能表现优越.
- 通过cPB增加来衡量动脉样硬化进展,同样独立地与全因死亡率有关.
结论:
- 通过cPB和CAC评估的亚临床动脉样硬化负担,可以独立预测无症状个体的全因死亡率.
- 动脉样硬化进展是所有原因死亡率的独立预测因素.
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