与代谢功能障碍相关的脂肪性肝病:面对现在和未来的病理生理学和临床框架
Salvatore Corrao1, Luigi Calvo2, Walter Granà2
1Department of Clinical Medicine, Internal Medicine Unit, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy; Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties [PROMISE], University of Palermo, Italy.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|October 2, 2024
概括
代谢功能障碍相关的脂肪性肝病 (MASLD) 是脂肪性肝病的新术语,强调代谢联系. 一个整体的,多专业的方法对于管理这种复杂的条件至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 内部医学 内部医学
背景情况:
- 脂肪性肝病包括一系列的疾病,其特点是脂肪在肝脏中的积累.
- 非酒精性脂肪性肝病 (NAFLD) 被代谢功能障碍相关的脂肪性肝病 (MASLD) 取代,以更好地反映其代谢基础.
- 了解代谢功能障碍和肝硬化症之间的复杂关系对于有效的管理至关重要.
研究的目的:
- 为了解代谢功能障碍相关的脂肪性肝病 (MASLD) 建立一个概念框架.
- 突出代谢功能障碍和伴随性疾病在脂肪肝疾病的背景下的重要性.
- 倡导一个整体的方法来管理脂肪性肝病.
主要方法:
- 这项研究是一项综述,综合了MASLD.目前的知识.
- 它分析了从NAFLD到MASLD的术语的转变.
- 它探讨了MASLD的多因素致病性.
主要成果:
- MASLD被提议作为新的术语,取代NAFLD,以强调代谢变化和肝脂肪之间的联系.
- 关键的因素包括中心肥胖,胰岛素抵抗,脂质代谢和遗传倾向.
- 复杂的途径涉及神经素和先进的甘化终端产品有助于MASLD的病变发生.
结论:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个复杂的临床挑战.
- 一个协调,多专业和多专业的干预策略对于成功管理至关重要.
- 整体方法对于解决MASLD的多面性质至关重要.
关键词:
亚迪波尼克丁氨酸是什么先进的糖化最终产品 (AGEs)中心肥胖症 中心肥胖症饮食因素 饮食因素胰岛素耐药性 胰岛素耐药性是一种脂质 脂质 是一种与代谢功能障碍相关的脂肪性肝病 (MASLD)非酒精性脂肪肝疾病 (NAFLD) 是一种非酒精性脂肪肝疾病.更多相关视频
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