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Updated: Jun 19, 2026

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微型蛋白质结合剂的新设计大致中和了Clostridioides difficile毒素B变体

Xinchen Lv1,2,3,4, Yuanyuan Zhang3,5,6, Ke Sun3,4

  • 1Research Center for Industries of the Future, Westlake University, Hangzhou, Zhejiang, 310024, China.

Nature communications
|October 2, 2024
PubMed
概括

科学家们设计了新的微型蛋白质结合剂,可以中和Clostridioides difficile毒素B (TcdB) 变种. 这些泛特异性结合剂具有高亲和力,在体外和体内有效中和TcdB,为C. difficile感染 (CDI) 提供潜在的治疗策略.

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Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...