在临床高风险和近期精神病发作的COMT,プロ林和负面症状之间的关系
James D Clelland1, Hannah Hesson2,3, Krista Ramiah1
1Clinical Research Department, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
患有精神病临床高风险 (CHR) 个体和近期发病 (RO) 个体的负面症状受到普罗林水平和COMT基因型的影响. 这种相互作用可能为早期干预提供新的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 负面症状显著损害了临床高风险 (CHR) 精神病和近期精神病发作 (RO) 的人的功能.
- 目前针对负面症状的治疗方法有限,这突显了对新型治疗点的需求.
- 甲基转移酶 (COMT) Val158Met多态性和プロ林代谢与精神病风险和症状严重程度有关.
研究的目的:
- 调查COMT Val158Met多态性和禁食血proline度对CHR或RO的青少年和年轻成年人的负面症状严重性的预测作用.
- 探索针对治疗干预的普罗林和COMT之间的相互作用的潜力.
主要方法:
- 评估了50名在CHR或RO的青少年和年轻成年人的队列.
- 消极症状使用消极症状评估尺度 (SANS) 和消极症状临床评估面试 (CAINS) 进行测量.
- 分析了与症状严重程度相关的禁食血proline度和COMT Val158Met基因型.
主要成果:
- 禁食血proline和COMT基因型之间的显著相互作用预测了SANS总和全球严重性评分 (p < 0.01) 上的负面症状 (p < 0.01).
- 较高的普罗林水平对Val/Val基因型个体有益,但对Met等位基因携带者有害.
- 对于预测CAINS分数和社会功能的COMT x proline相互作用,观察到一种显著性的趋势.
结论:
- 外周普罗林度和COMT基因型之间的相互作用会影响CHR或RO的年轻个体的负面症状.
- 这些发现表明,林水平和COMT基因型可能是重要的生物标志物和精神病早期干预的潜在治疗点.
- 针对这种相互作用途径可能会导致针对难以治疗的负面症状的新型治疗方法.
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