饮食习惯和遗传敏感性:营养摄入量与精神分裂症和双相情感障碍的遗传风险之间的相关性
Kazutaka Ohi1,2,3, Daisuke Nishizawa4,5, Taiga Saito6
1Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan. ohi.kazutaka.h8@f.gifu-u.ac.jp.
对精神分裂症 (SCZ) 和双相情感障碍 (BD) 的遗传倾向会影响老年人的饮食习惯. 具有较高遗传风险的个体减少了富含营养的食物,如浅色蔬菜和大豆的摄入量.
科学领域:
- 营养精神病学 营养精神病学
- 遗传流行病学遗传流行病学
- 老年医学 老年医学
背景情况:
- 饮食习惯与预防和治疗精神分裂症 (SCZ) 和双相情感障碍 (BD) 有关.
- 遗传和环境因素影响饮食模式和SCZ和BD的风险.
- 了解这些联系可以为预防性心理健康策略提供信息.
研究的目的:
- 研究SCZ和BD遗传倾向对生活方式相关疾病的老年人饮食习惯的影响.
- 探索基于遗传风险和饮食摄入量的潜在预防性心理健康策略.
主要方法:
- 分析了730名患有生活方式相关疾病的老年人队列.
- 评估了八种饮食类别:米索,日本茶,绿色/黄色蔬菜,浅色蔬菜,水果,酸菜,肉类和大豆.
- 对SCZ和BD (包括BD I和BD II) 的多基因风险评分 (PRS) 使用大规模GWAS数据计算.
主要成果:
- 对于SCZ和BD的PRS风险与减少淡色蔬菜和大豆的消费有显著的相关性.
- 与BD II相比,BD I的遗传风险对蔬菜摄入有更明显的影响.
- 对SCZ和BD的共同遗传因素与低摄入量米索,日本茶,浅色蔬菜和大豆有关.
结论:
- 对SCZ和BD的共同遗传风险会影响老年人的饮食选择.
- 饮食修改可以作为SCZ和BD预防和治疗综合战略的组成部分.
- 这些发现凸显了老年人群中遗传,饮食和心理健康之间的相互作用.
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