通过在真菌中植入细菌来诱导新的内共生
Gabriel H Giger1, Chantal Ernst1, Ingrid Richter2
1Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland.
Nature
|October 2, 2024
概括
研究人员通过将细菌植入真菌中来人工诱导内共生. 随着选择,真菌适应,使细菌传播和代谢功能转移成为可能,为共生起源提供了洞察力.
科学领域:
- 微生物学
- 进化生物学
- 菌群学
背景情况:
- 内生共生对于进化创新和生态多样化至关重要.
- 这种新出现的内共生是罕见的,而且很难以后来研究.
研究的目的:
- 通过实验诱导和研究内共生的早期阶段.
- 在新生共生中研究适应性进化和功能转移.
主要方法:
- 将细菌 (大肠杆菌,Mycetohabitans rhizoxinica) 人工植入细丝菌Rhizopus microsporus中
- 应用连续的正选择来促进内共生.
- 对宿主突变和细菌代谢功能的分析 (素生成).
主要成果:
- 大肠杆菌诱导宿主细胞分裂,停止了内共生.
- Mycetohabitans rhizoxinica显示低频垂直传播,随着选择而改善.
- 适应性进化减轻了适应性成本,导致宿主突变和成功转移树根素生产.
结论:
- 人工内生共生是一种可行的实验模型来研究共生起源.
- 持续的选择推动了新形成的内生生态的适应和功能融合.
- 这种方法有助于研究内共生出现和合成生物学应用中的关键事件.
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