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Updated: Jun 11, 2025

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MHC Hammer揭示了癌症进化中的遗传和非遗传HLA干扰

Clare Puttick1,2,3, Thomas P Jones2,3, Michelle M Leung1,2,3

  • 1Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Nature genetics
|October 2, 2024
PubMed
概括

第I类人类白细胞抗原 (HLA) 破坏在癌症中很常见,涉及抑制和替代拼接. 这种免疫逃避机制影响瘤的演变和转移,特别是在肺癌和乳腺癌中.

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