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饮食干预对子宫内膜异位症的影响:随机对照试验的系统审查和元分析

Jéssica Kleinkauff Meneghetti¹, Mirela Tschiedel Pedrotti², Isabel Meneghetti Coimbra²

¹Postgraduate Program in Medical Sciences, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350/1124, Porto Alegre, RS, CEP:90035-903, Brazil. jkmeneghetti@gmail.com.

Reproductive sciences (Thousand Oaks, Calif.)

|October 2, 2024

概括

饮食干预措施显示出降低子宫内膜异位症疼痛的潜力,特别是经期不良,但证据质量有限. 需要更多高质量的试验来证实子宫内膜异位症管理中的营养补充剂的疗效和安全性.

科学领域:

妇科妇科妇科妇科
营养科学营养科学
基于证据的医学基于证据的医学.

背景情况:

子宫内膜异位症是一种慢性疾病,影响生殖年龄的女性.
疼痛管理仍然是子宫内膜异位症患者面临的重大挑战.
饮食干预正在被探索为补充疗法.

研究的目的:

系统地审查随机临床试验 (RCT) 关于饮食干预对子宫内膜异位症的影响.
评估营养补充剂对子宫内膜异位症相关疼痛症状的影响.

主要方法:

在多个数据库 (PubMed,CENTRAL,CINAHL等) 进行了搜索. 对于相关的RCT来说.
包括11个RCT与716名妇女;6个RCT (457名妇女) 进行了元分析.
在包含的研究中评估偏差和异质的风险.

主要成果:

大多数研究表明对子宫内膜异位症疼痛评分有积极影响,但偏差风险中等至高.
与安慰剂相比,抗氧化剂补充剂显著降低了经期障碍症.
补充剂并没有显著减少慢性盆腔疼痛或脊髓功能障碍.
在元分析中观察到很高的异质性;低偏差的研究没有显示出任何显著的结果.

结论:

营养化合物可能具有降低子宫内膜异位症疼痛的潜力,尤其是经经经障.
目前的证据受到现有研究中高异质性和偏差风险的限制.
需要进一步进行高质量的RCT,以确定食疗干预措施对子宫内膜异位症疼痛管理的疗效和安全性.

关键词:

在CRD42020196712中使用.

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