由 Bacillus subtilis 生物转化的大刺激肠道免疫系统并调节肠道微生物群组成
Genevieve Tonog1, Hyeonjun Yu2, Sung-Kwon Moon1
1Department of Food and Nutrition, Chung-Ang University, Anseong, 17546, South Korea.
Molecular nutrition & food research
|October 3, 2024
概括
生物转化大酵素 (BGFs) 通过促进免疫细胞的增殖和细胞因子的产生来增强肠道免疫力. BGF还调节肠道微生物群,增加有益的细菌并支持肠道健康.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠道免疫系统在维持整体健康方面发挥着至关重要的作用.
- 调节肠道微生物群组成是增强免疫功能的关键策略.
研究的目的:
- 评估生物转化大酵素 (BGFs) 刺激肠道免疫系统的潜力.
- 为了研究BGFs对菌群组成的影响.
主要方法:
- 在体外测试评估骨髓细胞增殖和细胞因子生产.
- 在体内研究涉及口服BGFs给C3H/HeN小鼠.
- 免疫细胞种群的分析,细胞因子水平 (IFN-γ,GM-CSF,IL-6,TNF-α,IgA) 和细胞微生物群组成 (族群和属级).
主要成果:
- 在体外,BGF显著增强了Peyer补丁介导的细胞增殖,增加了IFN-γ,GM-CSF,IL-6和IGA的产生.
- 在小鼠中,口服BGF给药导致皮耶尔斑块,小肠液和血清中GM-CSF,IFN-γ和TNF-α的水平增加.
- BGFs调节了肠道微生物群,增加了Bacteroidota和Verrucomicrobiota,同时降低了Actinobacteria和Bacillota在类层面. 增加了像Fusimonas,Bacteroides和Akkermansia这样的特定属,而减少了Bifidobacterium和Limosilactobacillus.
结论:
- 这项研究提供了第一个证据,即BGFs可以调节肠道免疫系统.
- BGFs显示出作为一种新型功能材料的潜力,通过免疫刺激和微生物群调节来增强肠道免疫力.
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