三十五年来,疫苗泄漏问题一直存在
M Elizabeth Halloran1,2, Claudio J Struchiner3,4
1Biostatistics, Bioinformatics and Epidemiology Program, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, United States.
American journal of epidemiology
|October 3, 2024
概括
"泄漏疫苗"一词在疫苗评估中已经使用了35年. 这篇论文追溯其起源于疟疾疫苗研究,并将其与所有或没有机制对比.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 流行病学方法 流行病学方法
- 数学建模的数学建模
背景情况:
- "漏洞疫苗"的概念在科学文献中已经流行了35年.
- 它的使用在数学建模和疫情学研究中用于疫苗评估是常见的.
- 这个术语的起源与20世纪80年代早期对虫疟疾疫苗的早期研究有关.
研究的目的:
- 提供关于"漏洞疫苗"一词的创造的历史记录.
- 要区分泄漏疫苗机制和所有或没有疫苗反应.
- 探索漏洞疫苗对研究设计和人口健康结果的影响.
主要方法:
- 科学文献和术语的历史评论.
- 疫苗机制的概念分析.
- 讨论对流行病学研究设计的影响.
主要成果:
- "泄漏疫苗"一词可能起源于20世纪80年代疟疾疫苗研究的背景.
- 漏洞疫苗不同于"全部或没有"疫苗,影响如何衡量疗效.
- 了解疫苗泄漏性对于适当的研究设计和解释人口层面影响至关重要.
结论:
- "泄漏疫苗"一词的历史背景对于当前的研究很重要.
- 对于准确的评估,区分疫苗机制 (漏洞性与全或无) 是至关重要的.
- 我们欢迎进一步的历史贡献,以充分记录该术语的演变.
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