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Updated: Jun 11, 2025

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在坐骨神经受伤后发生EZH2依赖的髓化.

Hui Zhu1, Li Mu2,3, Xi Xu1,4

  • 1Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu Province, China.

Neural regeneration research
|October 3, 2024
PubMed
概括

增强质同源2 (EZH2) 对于施万细胞髓化和外围神经再生至关重要. 在小鼠中减少EZH2会损害损伤后的神经修复和复髓化,这表明EZH2是治疗点.

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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