接受生物治疗的斑块牛皮患者的湿疹反应:一项观察性研究
M Burlando1, M Megna, G Caldarola
1Dermatologic Clinic, D.I.S.S.A.L., Genoa University, Genoa, Italy. martina.burlando@unige.it.
European review for medical and pharmacological sciences
|October 3, 2024
概括
牛皮的生物治疗可以引起湿疹,特别是使用抗-17 (IL-17) 剂. 转换为抗联素-23 (IL-23) 疗法有效地解决了这些反应,特别是在有过亚托皮病史的患者中.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对瘤坏死因子 (TNF) -α和互白素 (IL) -17A的生物药物用于牛皮.
- 包括湿疹反应在内的皮肤副作用是这些生物治疗的已知并发症.
- 在生物治疗期间导致湿疹反应的因素需要进一步阐明.
研究的目的:
- 为了研究用生物药物治疗的牛皮患者的湿疹喷发的临床特征和管理.
- 为了识别与疹的发展相关的因素,在抗素-17 (IL-17) 或抗素-23 (IL-23) 治疗期间.
主要方法:
- 意大利的观察性,回顾性,多中心研究.
- 这项研究涉及54名患有慢性斑块性牛皮的患者,在开始抗IL-17或抗IL-23治疗后出现了湿疹.
- 评估临床特征和治疗结果.
主要成果:
- 在受影响的患者中,亚托皮病史 (个人或家族) 是常见的.
- 湿疹反应发生在开始生物治疗后的几天和几年之间.
- 抗IL-17药物与湿疹反应的比例最高有关.
- 转换为抗IL-23药物导致湿疹的快速和持续缓解.
- 快速响应牛皮治疗的人似乎经历了更持久的湿疹反应.
结论:
- 患有牛皮和亚托皮性皮炎病史的患者可能受益于IL-23抑制剂.
- IL-23抑制剂在牛皮治疗中表现出有效性,报告的湿疹反应发生率较低.
- 切换到IL-23抑制剂是治疗牛皮时生物诱导性湿疹的有效策略.
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