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Updated: Jun 11, 2025

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation
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A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation

Published on: March 27, 2017

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在Aβ42粉样蛋白形成中捕获虚幻的环状中间体

Yu Yuan1, Xiaozhe Dong1, Huan Wang1

  • 1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

Biophysics reviews
|October 3, 2024
PubMed
概括

研究人员使用液相传导电子显微镜可视化了粉样纤维形成中的环状中间体. 发现空气液体接口可催化粉样β 42 (Aβ42) 的聚合,这是与阿尔茨海默病相关的.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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