在2019年冠状病毒病 (COVID-19) 的住院患者中,血清瘤缩因子-α状态
Mansour Babaei1,2, Behzad Heidari1,2, Mahmoud Sadeghi Haddad Zavareh2
1Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Caspian journal of internal medicine
|October 3, 2024
概括
住院COVID-19患者的血清瘤坏死因子-α (TNF-α) 水平升高,表明潜在的疾病严重程度. 这些水平在性别和年龄组之间有所不同,这表明2019年冠状病毒疾病的个性化治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 关键护理医学 关键护理医学
背景情况:
- 瘤坏死因子-α (TNF-α) 是炎症反应和病毒感染控制中的关键细胞因子.
- 提升的TNF-α与各种炎症状况和疾病病原发生有关.
研究的目的:
- 在被诊断为COVID-19的住院患者中调查TNF-α的血清水平.
- 探索TNF-α水平,患者人口统计 (性别,年龄) 和疾病严重程度之间的关联.
主要方法:
- 采用了横截面研究设计.
- 在91名COVID-19患者中确定了血清TNF-α水平,性别和年龄.
- 统计分析包括t测试,ANOVA和使用SPSS-18.8.的逻辑回归.
主要成果:
- 所有患者 (100%) 的血清TNF-α水平高于正常范围 (平均9.9 pg/mL).
- 严重的COVID-19病例 (95.60%) 的平均TNF-α值为10.20 pg/mL.
- 与男性 (8.8 pg/mL) 相比,女性 (11.37 pg/mL) 和70岁以上的个人 (11.30 pg/mL) 观察到更高的TNF-α水平.
结论:
- 在COVID-19患者,特别是老年人和女性中,血清TNF-α度升高可能与疾病严重程度相关.
- 在性别和年龄组之间观察到的TNF-α水平的差异表明,在COVID-19管理中可能需要量身定制的治疗干预措施.
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