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在超重和肥胖儿童和青少年的甲状腺功能测试中,有或没有非酒精性脂肪肝疾病
Armineh Barzegar1, Morteza Alijanpour2, Mohammadreza Esmaeili Dooki2
1Student Research Committee, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Caspian journal of internal medicine
|October 3, 2024
概括
这项研究发现,患有非酒精性脂肪肝疾病 (NAFLD) 和没有非酒精性脂肪肝疾病的超重/肥胖儿童之间的甲状腺激素没有显著差异. 在这两组中都没有观察到甲状腺功能下降,这表明甲状腺功能不是儿科NAFLD发展的主要因素.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 非酒精性脂肪肝 (NAFLD) 在儿童和青少年中越来越普遍.
- 甲状腺功能低下症被认为是NAFLD发展的潜在因素.
- 这项研究调查了甲状腺功能在超重和肥胖个体中儿科NAFLD中的作用.
研究的目的:
- 为了比较甲状腺功能测试 (TSH,T4) 在超重和肥胖的儿童和青少年和没有NAFLD.
- 评估其他代谢参数,包括脂质概况,葡萄糖和维生素D水平,与该人群中的NAFLD相关.
- 为了确定甲状腺功能低下是否与儿科病例中的NAFLD有关.
主要方法:
- 进行了一项涉及100名儿童和青少年 (4-18岁) 的病例控制研究.
- 根据身体检查,BMI和腹部超声波,参与者被分为病例 (NAFLD) 和控制 (没有NAFLD) 组.
- 测量了甲状腺功能测试 (TSH,T4),代谢标记 (FBS,脂质概况,25(OH) 维生素D3) 和肝酶 (AST,ALT).
主要成果:
- 在NAFLD和对照组之间没有观察到平均TSH,T4,FBS,胆固醇,LDL或维生素D水平的显著差异.
- 然而,在两组之间的平均AST,ALT,甘油三 (TG),HDL和BMI中发现了显著的差异.
- 在任何参与者中都没有检测到甲状腺功能低下症.
结论:
- 甲状腺激素水平在超重/肥胖儿童和没有NAFLD之间没有显著差异.
- 这些发现表明,甲状腺功能低下症在这个儿科队列中不是NAFLD发展的重要因素.
- 建议对更大样本和更长的随访期进行进一步的研究,以证实这些发现.
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